Top Multi-State Cannabis Operators (MSOs) in Florida

Florida’s medical cannabis market continues to grow at a rapid pace, and Multi-State Operators (MSOs) are leading the charge. These companies have made significant investments in the state, setting up dispensaries and cultivation centers to meet the growing demand for medical cannabis. Here’s a look at the top four MSOs in Florida, their locations, and the states they operate in where recreational cannabis is also legalized.

1. Trulieve

Trulieve is the largest MSO in Florida and dominates the state’s medical cannabis market. With over 130 dispensaries across Florida, it is known for its extensive product line, which includes flower, concentrates, edibles, and tinctures. Trulieve operates in key cities across the state, such as:

  • Miami
  • Tallahassee
  • Tampa
  • Jacksonville

Trulieve has also expanded beyond Florida, operating in states like Arizona, California, and Massachusetts, where recreational cannabis is legalized. The company is known for its vertical integration, meaning they oversee the entire cannabis process from cultivation to retail.

Source: Trulieve Official Website

2. Curaleaf

Curaleaf is another major player in Florida’s cannabis market, operating more than 50 dispensaries statewide. Their offerings include flower, vapes, topicals, and edibles, catering to a wide range of medical conditions. Curaleaf dispensaries can be found in key locations like:

  • Orlando
  • West Palm Beach
  • Miami
  • Tampa

Curaleaf’s reach extends far beyond Florida, with operations in over 23 states, including California, Massachusetts, and New Jersey, where recreational cannabis use is also legal. The company is focused on product innovation and is constantly expanding its product lines.

Source: Curaleaf Official Website

3. Verano Holdings (MÜV Dispensaries)

Verano Holdings operates under the MÜV dispensary brand in Florida, with a focus on high-quality, medical-grade cannabis products. The company has over 60 dispensaries in Florida, located in cities such as:

  • Fort Lauderdale
  • West Palm Beach
  • Port St. Lucie
  • Orlando

Verano has expanded its operations into states with both medical and recreational cannabis markets, including Illinois, Nevada, and New Jersey. Its vertical integration model ensures that its products are consistent and high-quality across all markets.

Source: Verano Holdings

4. Ayr Wellness (Liberty Health Sciences)

Ayr Wellness, which operates under the Liberty Health Sciences brand in Florida, has built a solid reputation for providing affordable, high-quality cannabis products. Ayr Wellness operates more than 50 dispensaries across the state, with key locations in:

  • Miami
  • Tampa
  • Gainesville
  • St. Petersburg

In addition to Florida, Ayr Wellness has expanded into states like Nevada, Massachusetts, and New Jersey, where recreational cannabis use is legal. Ayr’s commitment to patient care and product diversity makes it one of the leading MSOs in Florida.

Source: Ayr Wellness

A Growing Presence

These top four MSOs—Trulieve, Curaleaf, Verano, and Ayr Wellness—are leading the charge in Florida’s medical cannabis industry. With dispensaries spread across the state and a strong presence in states with recreational markets, these companies are setting the standard for cannabis cultivation, production, and patient care. As the demand for cannabis continues to rise, these MSOs are well-positioned to meet the needs of patients and consumers alike.


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